Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome

H Sugita, S Nakanuma, S Munesue… - Journal of …, 2024 - Wiley Online Library
hepatectomy is important for patients with colorectal liver … of cilostazol (CZ), an oral selective
phosphodiesterase III … VWF in zone 3 and the increase in blood HA levels after hepatectomy …

Cilostazol induces apoptosis and inhibits proliferation of hepatocellular carcinoma cells by activating AMPK

KH Sim, MS Shu, S Kim, JY Kim, BH Choi… - Biotechnology and …, 2021 - Springer
… Kollmar, and MD Menger (2014) The phosphodiesterase 3 inhibitor cilostazol does not
stimulate growth of colorectal liver metastases after major hepatectomy. Clin. Exp…

Platelet-targeted pharmacologic treatments as anti-cancer therapy

P Gresele, S Momi, M Malvestiti… - Cancer and Metastasis …, 2017 - Springer
… Different isoforms of phosphodiesterases are present in … Combination therapy with cisplatin
and cilostazol may increase the … lobe in non-hepactomized rats and in 2/3 hepatectomized

Phosphodiesterase 3A represents a therapeutic target that drives stem cell–like property and metastasis in breast cancer

N Hao, W Shen, R Du, S Jiang, J Zhu, Y Chen… - Molecular Cancer …, 2020 - AACR
… the stemness of colorectal cancer. More interestingly, it … -selective inhibitor cilostazol
reduces breast cancer cell stem cell… –metastasis environment are thought to promote breast …

[PDF][PDF] PDE3 inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space

宮田隆司 - 2018 - kanazawa-u.repo.nii.ac.jp
… the effects of cilostazol (CZ), a phosphodiesterase III inhibitor, in a … -induced SOS6 and in
a rat model of hepatectomy.PAI-1 … in patients with metastatic colorectal cancer. Ann. Oncol. …

[HTML][HTML] Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation

T Miyashita, S Nakanuma, AK Ahmed, I Makino… - European Surgery, 2016 - Springer
… the liver is a major complication of hemorrhagic shock, liver resection, … inhibitor-1, and
transforming growth factor-β, may induce portal … of hepatic fibrosis, as well as suppression of liver

Cilostazol enhances mobilization of circulating endothelial progenitor cells and improves endothelium-dependent function in patients at high risk of cardiovascular …

TH Chao, IC Chen, CH Lee, JY Chen, WC Tsai… - …, 2016 - journals.sagepub.com
Cilostazol, a phosphodiesterase 3 inhibitor, has both antiplatelet … have protective effects
against the development and … in FMD did not significantly correlate with the increase in the …

Influence of Mesenchymal Stem Cell Administration on the Outcome of Partial Liver Resection in a Porcine Model of Sinusoidal Obstruction Syndrome

R Palek, J Rosendorf, A Maleckova… - Anticancer …, 2020 - ar.iiarjournals.org
colorectal liver metastases, the possibility for radical liver resection … prevented SOS
development after HSCT (35). As it … was to evaluate whether administration of MSC can improve

[HTML][HTML] Safety of laparoscopic surgery in digestive diseases with special reference to antithrombotic therapy: a systematic review of the literature

T Fujikawa, K Ando - World Journal of Clinical Cases, 2018 - ncbi.nlm.nih.gov
… proportion of IBC or PBC did not increase, even with heparin bridging[… three types of surgery;
one study on laparoscopic liver resection[16], two studies on laparoscopic colorectal cancer

[HTML][HTML] cAMP signaling in pathobiology of alcohol associated liver disease

M Elnagdy, S Barve, C McClain, L Gobejishvili - Biomolecules, 2020 - mdpi.com
… rate of degradation by phosphodiesterases. cAMP signaling … six weeks followed by 70%
partial hepatectomy (PH) [100]. … ) and the PDE3 inhibitor, Cilostazol, on liver injury has also been …